MARJA I. ROSLUND, RIIKKA PUHAKKA, MIRA GRÖNROOS, NOORA NURMINEN, SAMI OIKARINEN, University of Helsinki, Tampere University, University of Eastern Finland, Charles University, University Hospital Motol, University of Eastern Finland

As the incidence of immune-mediated diseases has increased rapidly in developed societies, there is an unmet need for novel prophylactic practices to fight against these maladies. This study is the first human intervention trial in which urban environmental biodiversity was manipulated to examine its effects on the commensal microbiome and immunoregulation in children. We analyzed changes in the skin and gut microbiota and blood immune markers of children during a 28-day biodiversity intervention. Children in standard urban and nature-oriented daycare centers were analyzed for comparison. The intervention diversified both the environmental and skin Gammaproteobacterial communities, which, in turn, were associated with increases in plasma TGF-β1 levels and the proportion of regulatory T cel

Palabras clave: salud, sistema inmune, naturaleza, beneficios